💊 Proton pump inhibitors 💊
Proton-pump inhibitors are a class of medications that cause a profound and prolonged reduction of stomach acid production. This is such a common drug class which you will come across in practice, It’s also included within the common medications in practice pocket book!
Examples:
- Lansoprazole
- OmeprazoleÂ
Suffix = PrazoleÂ
Mechanism of action
PPI's work by irreversibly binding to gastric H+/K+ ATPase also known as the 'proton pump', in the parietal cells of the stomach and preventing acid secretion.Â
When taken 30 to 60 minutes before a meal, PPIs can prevent or reduce heartburn. However, they do not work as well when taken on demand as they do when taken over a period of time.
Side Effects
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MEMORY TRICK - Mnemonic = 'ACID'
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- Abdominal pain/ nausea/ vomiting
- C.diff infection
- Interstitial nephritis
- Decreased vitamin B12 absorptionÂ